<![CDATA[This study analyzes the effect of domain filtering on drug recommendation systems based on association rule mining using the FP-Growth algorithm with Neural Collaborative Filtering (NCF) as a comparison. The dataset used was derived from patient medical records containing attributes such as complaints, diagnoses, and drug therapies, with a total of 1,000 patient transactions. To avoid data leakage, the dataset was randomly divided into 70% training data and 30% test data before the modeling process was carried out. Domain filtering was applied by limiting the rule structure so that complaints and diagnoses acted as antecedents and drugs as consequents. The performance of the recommendation system was evaluated using the Precision@5, Recall@5, and Normalized Discounted Cumulative Gain (NDCG@5) metrics. The results of the experiment show that the FP-Growth approach with domain filtering produces higher Precision@5 and NDCG@5 values than the non-filtering approach. The Wilcoxon Signed-Rank test shows that the difference is statistically significant, while effect size analysis using Cliff's Delta shows a practically meaningful impact. Furthermore, a comparison with Neural Collaborative Filtering shows that the collaborative filtering-based approach is less effective on transactional clinical prescription data with limited historical interactions. These findings indicate that integrating medical domain knowledge into FP-Growth can improve the clinical relevance and quality of drug recommendation rankings]]>
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