The effectiveness of health interventions is determined by multiple factors, such as leadership, participation, and environmental support. This study analyzes the determinants and most influential factors contributing to the success of health interventions. A quantitative approach with a cross-sectional analytical design was employed, involving 194 respondents selected through proportional random sampling. Data analysis utilized the chi-square test and logistic regression. The findings indicate that leadership capacity (p=0.021; OR=2.130), participation (p=0.000; OR=3.640), communication skills (p=0.000; OR=8.016), support in decision making (p=0.000; OR=4.800), access to health facilities (p=0.000; OR=4.759), local culture and norms (p=0.012; OR=2.231), transformational leadership style (p=0.000; OR=15.171), and servant leadership style (p=0.011; OR=2.231) significantly affect the success of health interventions. In contrast, community credibility and trust (p=0.869) and regional policies (p=0.843) do not demonstrate a significant effect. These results confirm that leadership quality and participatory support, particularly transformational leadership style and effective communication skills, are critical to the success of health interventions.
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