Biomedika
Vol 18, No 1 (2026): Biomedika February 2026

DIAGNOSTIC TEST OF NEUTROPHIL LYMPHOCYTE RATIO IN CONFIRMED COVID-19 POSITIVE PATIENT AT RSUD WONOSARI

Muhammad Ariq Naufal Arofiq (Universitas Islam Indonesia, Sleman)
Linda Rosita (Universitas Islam Indonesia, Sleman)
Utami Mulyaningrum (Universitas Islam Indonesia, Sleman)



Article Info

Publish Date
01 Feb 2026

Abstract

Coronavirus Disease 2019 (Covid-19) is an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The neutrophil lymphocyte ratio (NLR) biomarker is used as a parameter of inflammatory reactions which is also frequently evaluated in Covid-19. In Covid-19 patients, there is often an increase in NLR through the mechanism of lymphocyte exhaustion. This research to identify the performance of NLR in a diagnostic test for confirmed Covid-19 patients at RSUD Wonosari. This study is analytical observational through a cross-sectional approach. Sampling used a consecutive sampling technique. The target population was suspected Covid-19 patients. Data were analyzed by univariate, ROC curve, and diagnostic tests. A total of 75 suspected Covid-19 patients were found 33 male patients (44%), 42 female patients (66%), and the most aged> 55 years were 52 patients (69.3%). RT-PCR results found 57 patients were positive for Covid-19 (76%) and 18 patients were negative for Covid-19 (24%). ROC curve obtained AUC value 0.785 (p<0.05; 95% CI 0.662-0.907) with cut-off point NLR≥ 2.33, sensitivity 91.2%, specificity 50%, NPV 64.3%, PPV 85.2%, LR+ 1.81, and LR- 0.17. NLR can be an initial diagnostic tool for Covid-19.

Copyrights © 2026






Journal Info

Abbrev

biomedika

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Description

Biomedika is one of the efforts of the Faculty of Medicine of University Muhammadiyah Surakarta to improve the academic atmosphere, as a publication of research results from lecturers and students. The existence of Biomedika is expected to enhance the activity and quality of research in medical and ...