<![CDATA[The orthodontic treatments of dentistry is to correct malocclusions. However, these treatments are difficult due to periodontal disorders involving alveolar bone resorption. Periodontitis is a chronic inflammatory disease leading to tooth loss. Flaxseed oil contains high omega-3 that can reduce inflammatory activity thereby reducing bone resorption. This study was conducted to prove the flaxseed oil enhance the osteoblasts number in periodontitis rats. This study was a purely experimental research with Randomized Post Test Only Control Group Design. Research subjects consisted of 8-12 week 32 white male rats of Sprague Dawley strain were divided into 2 groups; a control group were given placebo (glycerin) orally for 21 days, whereas the treatment group were given flaxseed oil 700 mg/200grBW orally for 21 days. On the 30th day, mice were euthanized for mandibula alveolar bone tissue sampling and histological preparations were made by HE (Harris Hematoxylin-Eosin) staining. The data were analyzed using SPSS program processed using Shapiro-Wilk for normality test and then continued using the independent t-test. The results showed that the mean of osteoblasts number at the treatment group by oral administration of flaxseed oil (64.62 ± 4.288 cells per 5 field of view) was significantly higher than the control group (36.56 ± 3.483 cells per 5 field of view). Test results based on comparison between the control group and the group treated with flaxseed oil with independent t-test showed that significant differences in the osteoblasts number and bone density of white male Sprague Dawley rats (p<0.05). This study concluded that there’s effect of oral administration of flaxseed oil enhance the osteoblasts number in white male rats of Sprague Dawley strain with periodontitis. Keywords: flaxseed oil, periodontitis, osteoblasts]]>
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