Green Synthesis of Polypogon monspeliensis–Based Silver Nanoparticles and Their Multifunctional Biomedical Potential

Alaa M. Alrudainy (Department of Renal Dialysis Techniques)
Ahmed Mshari (Department of Community Health Techniques, College of Health and Medical Technology Southern Technical University, Basrah)

Academia Open
Vol. 11 No. 1 (2026): June

General Background: Green synthesis of silver nanoparticles has gained attention as a sustainable approach to produce bioactive nanomaterials for biomedical use. Specific Background: Polypogon monspeliensis contains diverse phytochemicals that can function as reducing and stabilizing agents in plant-mediated nanoparticle synthesis. Knowledge Gap: Its potential as a green bioresource for fabricating multifunctional silver nanoparticles remains insufficiently explored. Aims: This study aimed to synthesize, characterize, and evaluate the antibacterial, antioxidant, and anticancer activities of P. monspeliensis–derived silver nanoparticles (Pol-AgNPs). Results: Pol-AgNPs were successfully synthesized, exhibiting crystalline, quasi-spherical particles (≈51–69 nm) with notable dose-dependent antibacterial activity, strong DPPH radical scavenging capacity, and selective cytotoxicity against A549 lung cancer cells. Novelty: The work demonstrates the dual functional role of P. monspeliensis extract in nanoparticle synthesis and bioactivity. Implications: Pol-AgNPs represent promising eco-friendly nanomaterials for future biomedical applications.Keywords : Green Synthesis, Polypogon Monspeliensis, Silver Nanoparticles (AgNPs), Antibacterial And Antioxidant Activity, Anticancer NanomaterialsHighlight : Plant extract reduced Ag+ yielding quasi-spherical, crystalline materials sized 51–69 nm. Dose-dependent antibacterial action strongest against Pseudomonas aeruginosa among tested pathogens. High radical scavenging and selective cytotoxicity toward A549 cells with limited normal fibroblast toxicity.