Pengaruh Pemberian Ekstrak Rumput Bambu (Lophatherum gracile) sebagai Hepatoprotektor pada Mencit Jantan (Mus musculus)

Zidan Imana Putra Fauzi (Faculty of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Sumatera Utara)
Des Suryani (Department of Anatomy and Histology, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Sumatera Utara)

Buletin Farmatera
Vol 12, No 1 (2027)

Abstract: The use of paracetamol in toxic doses can cause impaired liver function. Bamboo grass is a plant that contains antioxidants, so it can be a hepatoprotector in protecting the liver from damage caused by paracetamol. The dose of Lopatherum gracile as a hepatoprotector has been studied in the dose range of 200 mg/kg body weight and 800 mg/kg body weight, with an effective dose result of 800 mg/kg body weight. The purpose of this study was to determine the effective dose of the hepatoprotector of bamboo grass extract against paracetamol-induced liver function in mice. This study is a true experiment with a post-test-only control group design. 5 groups were given treatment for 7 days, namely the negative control group (C-), positive control (C+), treatment 1 (T I): 400 mg/kg body weight, treatment 2 (T II): 600 mg/kg body weight, and treatment 3 (T III): 800 mg/kg body weight.  The SGOT and SGPT levels between groups were analysed by one-way ANOVA and post hoc Bonferroni. The results of the ANOVA test showed a significant difference in the level of SGOT and SGPT, namely p=0.001. The post hoc test showed no significant difference in SGOT and SGPT levels between T(II) and T(III), with negative controls of p:0.242, and p:0.100, and there was no significant difference in average SGOT between T2 and T3. The effective dose of hepatoprotector of bamboo grass extract in a group of paracetamol-induced mice was 600 mg/kg body weight.