Analisis LC-MS/MS Senyawa Metabolite Ekstrak Etanol daun Miana (Coleus scutellariodes (L) Benth) dan Potensinya sebagai Kandidat Obat Alzheimer

Julius Alvin Novensius Sinurat (Program Studi Kimia, Fakultas Sains dan Teknologi, Universitas Jambi, Indonesia)
Catherine Putri Bulan (Program Studi Kimia, Fakultas Sains dan Teknologi, Universitas Jambi, Indonesia)
Veronika Vitadella (Program Studi Kimia, Fakultas Sains dan Teknologi, Universitas Jambi, Indonesia)
Madyawati Latief (Program Studi Kimia, Fakultas Sains dan Teknologi, Universitas Jambi, IndonesiaNatural Product and Bioactive Compound Laboratory, Fakultas Sains dan Teknologi, Universitas Jambi, Indonesia)
Indra Lasmana Tarigan (Program Studi Kimia, Jurusan MIPA, Fakultas Sains dan Teknologi, Universitas Jambi)

PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Jurnal Pharmacy, Vol. 21 No. 02 Desember 2024

A secondary metabolic compound in plants is a bioactive substance connected to the chemical content of the plant, so some can be used as a medicine. Miana (Coleus Scutellariodes (L) Snapped) is a medicinal plant that has a potentially potent bioactive compound as an anticancer. Extraction of miana leaf with ethanol solvents held by an analysis of lc-ms, which shows some metabolite compounds contained in the miana. The method used is the extraction of miana leaves with ethanol, the study of compounds obtained from lc-ms, for the compound screening using Pchembl and ChemSpider websites and Pchembl's web server. The purpose of this research is to know and predict the potential of the associated bioactivity of the compounds found as candidates for new drugs. The results derived from this study are metabolite compounds found in the miana that are potentially Alzheimer drugs based on the screening done using Pchembl webservers based on a target protein acquired from extracting is acetylcholinesterase, which contains acetylcholinesterase as the target molecule that ACTS as an Alzheimer drug