Journal of Innovation and Applied Technology
Vol 2, No 2 (2016)

THE EFFECT OF CRUDE EXTRACT ALGINATE Sargassum crassifolium POWDER FOR CHOLESTEROL TOTAL LEVEL ON RATS (Rattus norvegicus)

Nandarningtiyas Laras Pratiwi (Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya)



Article Info

Publish Date
21 Dec 2016

Abstract

Dietary fiber in alginate of Sargassum crassifolium is one way to reduce high cholesterol level. The purpose of this researchshowedthe effect of crude extract alginat powder for reduced lipid profile on rats.The crude extract alginate powder was given orally to hyperlipidemia rats at the doses level of 100 mg/kg, 200 mg/kg, 400 mg/kg, and 800 mg/kg body weight for 20 days. The method of profile lipid analyse used CHOD PAP and GPO PAP.  The result showed that the growth of weight body and feed consumption did not give a significant effect (p>0.05), in the other hand it has a significant effect (p<0.05) on the cholesterol level , trygliseride level, HDL level, LDL level, VLDL level and cholesterol level in feses. For 20 dayscrude extrac alginate Sargassum crassifolium reduced cholesterol total level for 800 mg/ dl body weight as much as 50,43%, 200 mg/dl to 40,45%, 100 mg/kg to 34,73% and control (+) which used simvastatin to 42,23%.   

Copyrights © 2016






Journal Info

Abbrev

jiat

Publisher

Subject

Computer Science & IT

Description

Article published Journal of Innovation and Applied Technology (JIAT) include the results of community service related to Community Development, Economic Development, Transfer and Diffusion of Technology, Innovation Science and Technology, Institutional Innovation, Development of Local Wisdom, Basic ...