<![CDATA[Global information systems (GIS) are essential for managing large scale data across industries such as healthcare, finance, and urban planning. As the volume and complexity of data continue to grow, there is an increasing need for systems that can handle these demands while maintaining reliability and scalability. This research explores the integration of semantic computing and predictive analytics as a solution to improve the performance of GIS. Semantic computing, through the use of ontologies and standardized data models, enhances data interoperability, allowing systems to interpret and exchange data meaningfully across diverse platforms. On the other hand, predictive analytics uses statistical methods and machine learning models to forecast system behavior and optimize resource allocation, ensuring systems remain adaptive under varying loads. By integrating these two methodologies, this study demonstrates how they can address key challenges in global information systems, such as fault tolerance, system adaptability, and real time decision making. The results show significant improvements in system reliability and scalability, as well as better performance under high data volumes and diverse user interactions. The integrated approach was tested in several use cases, including urban planning, healthcare, and supply chain management, with results indicating that systems utilizing both semantic computing and predictive analytics are more resilient, accurate, and efficient. This paper discusses the practical implications of this integration for global scale applications and suggests future research directions, including the incorporation of emerging technologies like blockchain and artificial intelligence to further enhance the capabilities of GIS.]]>
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