Diabetic foot ulcer (UKD) is a chronic complication of diabetes mellitus that often experiences infection and is at risk of amputation if not treated properly. Ozone therapy is known to have antimicrobial effects, improve tissue oxygenation, and accelerate granulation and epithelialization of wounds. This study aims to describe the effectiveness of ozone therapy in reducing infection in UKD at the ETN Centre Makassar Care House. The case study was conducted on a 66-year-old Mrs. S patient with a 20-year history of diabetes and ulcers that lasted two months. Treatment was carried out over three visits using ozone therapy, PHMB irrigation, debridement, and modern dressing. The results showed improvements in the form of a decrease in wound size, exudate, loss of necrotic tissue, as well as an 85% increase in granulation and 20% epithelialization. These findings are consistent with previous research that states that ozone therapy is able to suppress bacterial colonization and speed healing. Conclusion: Ozone therapy is effective as an additional intervention in reducing UKD infection
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