Journal of Novel Engineering Science and Technology
Vol. 5 No. 01 (2026): Journal of Novel Engineering Science and Technology

Federated Quantum Machine Learning for Secure Multi-Party Genomic Data Analysis: A Hybrid Architecture with Differential Privacy

David Jumpa Malem Sembiring (Institut Teknologi dan Bisnis Indonesia)
Sinek Mehuli Br Perangin Angin (Institut Teknologi dan Bisnis Indonesia)



Article Info

Publish Date
04 May 2026

Abstract

The exponential growth of genomic data has created opportunities for collaborative biomedical research while posing significant privacy and security challenges. Traditional centralized machine learning approaches risk data breaches and regulatory non-compliance. This study proposes a novel hybrid architecture combining Federated Quantum Machine Learning (FQML) with Differential Privacy (DP) for secure multi-party genomic data analysis. Our simulated framework enables institutions to collaboratively train quantum machine learning models on distributed genomic datasets without exposing sensitive data. Using variational quantum circuits within a federated learning framework, we implement privacy-preserving models across three simulated genomic data silos. Gaussian noise injection via DP mechanisms during gradient updates ensures formal privacy guarantees (ε = 0.85). Experimental results on synthetic datasets demonstrate that FQML achieves 93.4% predictive accuracy in genome-wide association studies simulation, outperforming classical federated models in convergence speed by 27% and reducing communication overhead by 19%. These findings suggest FQML with DP provides a promising foundation for future secure genomic collaboration, though real-world validation remains necessary.

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Journal Info

Abbrev

JNEST

Publisher

Subject

Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Environmental Science Mechanical Engineering

Description

Journal of Novel Engineering Science and Technology is a multi-disciplinary international open-access journal dedicated to natural science, technology, and engineering, as well as its derived applications in various fields. JNEST publishes high-quality original research articles and reviews in all ...