ABSTRACT Sexually Transmitted Infections (STIs) are a common health problem among adolescents due to a lack of knowledge and sub optimal preventive behavior. This study aims to analyze the relationship between adolescents' knowledge of reproductive health and their STI prevention behavior. The research method used a quantitative approach with a cross-sectional design with 150 adolescent respondents. Data were collected using a questionnaire and analyzed using chi-square and t-tests. The results showed that adolescents with a good level of knowledge had better preventive behavior (p<0.05). It was concluded that there is a significant relationship between knowledge and STI prevention behavior.
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