<![CDATA[ABSTRACT Background: Septic shock is a life-threatening condition characterized by cardiovascular dysfunction, which can cause multi-organ failure and high mortality rates. Central venous oxygen saturation (SCVO2), PCO2 Gap, and Respiratory Quotient are potential markers of tissue perfusion and oxygenation, while cardiac output is an important indicator of cardiovascular function. So it is hoped that the results of this research can be a guide in the management and prediction of the prognosis of septic shock patients.Objective: To determine the correlation between central venous saturation (ScVO2), PCO2 Gap (Arterial-venous PCO2 Gradient) and Respiratory Quotient on Cardiac Output in septic shock patients.Methods: This observational study was conducted on 30 septic shock patients treated in the intensive care unit. The patient's blood sample is taken via a central venous catheter and arterial line to check central venous saturation (2ScVO2), PCO2 gap and calculate the respiratory quotient. Then cardiac output (Cardiac Output) is measured using Echohemodynamics.Results: Based on analysis using the Spearman Rho test, the results show that the correlation between ScVO2 and Cardiac Output has a correlation value of -0.367 (p = 0.046). The correlation between PCO2 Gap and Cardiac output has a correlation value of -0.520 (p=0.003). The correlation between respiratory quotient and cardiac output in this study had a correlation value of -0.833 (p < 0.001).Conclusion: There is a correlation between ScVO2, PCO2 Gap (Arterial-venous PCO2 Gradient) and Respiratory Quotient on Cardiac Output in septic shock patients. Keywords: Septic shock, ScVO2, PCO2 Gap, Respiratory Quotient, Cardiac output ]]>
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