<![CDATA[Low levels of knowledge about diabetes mellitus in patients can affect their attitudes toward therapy. This lack of understanding regarding disease management can impact adherence to therapy and self-care behaviors This study aims to determine the relationship between the level of knowledge and patient attitudes in undergoing diabetes mellitus therapy. This study used a correlational design with a cross-sectional approach. The study population was all diabetes mellitus patients treated in the Sedap Malam Ward of Gambiran Regional Hospital. A sample of 15 respondents was selected using accidental sampling. Data were collected using a questionnaire and analyzed using the Spearman Rho test with a significance level of α = 0.05. The results showed that 11 respondents (73.3%) had insufficient knowledge, 3 respondents (20%) had sufficient knowledge, and 1 respondent (6.7%) had good knowledge. Regarding the attitude variable, 12 respondents (80%) had negative attitudes and 3 respondents (20%) had positive attitudes towards diabetes mellitus therapy. The statistical analysis showed a p-value of 0.001, indicating a significant relationship between the level of knowledge and patient attitudes towards therapy. There is a significant relationship between patient knowledge and attitudes toward diabetes mellitus therapy. The better a patient's knowledge, the more positive their attitude toward therapy.Keywords: Knowledge, Attitude, Diabetes Mellitus]]>
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