Jurnal Sehat Indonesia (JUSINDO)
Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)

Comparing the Oncological Risk of Hormonal and Non-Hormonal Contraceptives in Cervical Cancer: A Literature Review

Hasna Putri, Haifa (Unknown)
Paramitha , Fiona (Unknown)



Article Info

Publish Date
12 May 2026

Abstract

Cervical cancer is a malignancy with high morbidity and mortality rates among women worldwide, including Indonesia. While high-risk HPV (hr-HPV) infection is the primary cause, contraceptive use is strongly suspected to act as a significant cofactor in cervical carcinogenesis. This research aims to analyze the comparison of cervical cancer risk between hormonal and non-hormonal contraceptive use through a comprehensive literature review. The study design was a literature review with a systematic search strategy on PubMed and Google Scholar databases. Ten original research articles (5 national and 5 international journals) published between 2016 and 2026 were selected based on inclusion and exclusion criteria. The analysis results showed that 60% of the studies reported a significant association between long-term hormonal contraceptive use ≥ 5 years and an increased risk of cervical cancer, with Odds Ratio (OR) values ranging from 2.4 to 7.0. In contrast, non-hormonal contraceptive use, specifically the Intrauterine Device (IUD), consistently showed a lower risk profile or provided a protective effect against pre-cancerous lesions. However, some studies showed variations influenced by confounding factors such as age at first marriage and parity. Long-term hormonal contraceptive use is associated with an increased risk of cervical cancer, while non-hormonal contraceptives (IUD) have a better oncological safety profile. Comprehensive counseling and routine screening (VIA/Pap Smear) are required for contraceptive acceptors, especially long-term hormonal method users.

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Journal Info

Abbrev

jsi

Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Description

Ruang lingkup dan fokus penelitian terkait bidang kajian dengan penekanan pada pendekatan, yang meliputi: Kesehatan Masyarakat, Kesehatan dan Keselamatan Kerja (Kesehatan Kerja; Hyperkes), Kebijakan Kesehatan (dan Analis Kesehatan), Ilmu Gizi, Epidemiologi, Teknik Kesehatan Lingkungan, Promosi ...