Formulasi dan Evaluasi Sediaan Nasal Spray Ekstrak Ubi Ungu (Ipomea batatas) Sebagai Kandidat Antihipertensi

Khairunnisa (Program Studi Farmasi Fakultas Ilmu Pengetahuan Alam Universitas Sriwijaya)
Meri Oktarina (Program Studi Farmasi Fakultas Ilmu Pengetahuan Alam Universitas Sriwijaya)
Retno Widiastuti (Program Studi Farmasi Fakultas Ilmu Pengetahuan Alam Universitas Sriwijaya)
Najma Annuria Fithri (Program Studi Farmasi Fakultas Ilmu Pengetahuan Alam Universitas Sriwijaya)
Fiony Larasati (Program Studi Farmasi Fakultas Ilmu Pengetahuan Alam Universitas Sriwijaya)

Journal of Pharmacy and Clinical Practice
Vol. 1 No. 2 (2026): Journal of Pharmacy and Clinical Practice

Purple sweet potato (Ipomoea batatas L.) is a source of anthocyanins known to have activity as an Angiotensin Converting Enzyme (ACE) inhibitor, thus having potential as an antihypertensive. This study aims to formulate and evaluate nasal spray preparations of purple sweet potato extract as candidates for intranasal drug delivery. The nasal spray preparations were formulated using 0.9% NaCl, PVP, PEG, MCC, and phosphate buffer pH 5.6. The evaluation included organoleptic tests, pH, clarity, pump-delivery, viscosity, sedimentation volume, and stability for 30 days. The results showed that all formulas were liquid, cloudy white, odorless, with a pH of 5.5–6, viscosity of 12–20 mPa·s, spray distribution of 25–30%, and sedimentation volume ≥0.8, and remained stable at room temperature and refrigerator. This study demonstrates that purple sweet potato extract nasal spray has physicochemical characteristics suitable for intranasal application, with potential for further development as an alternative natural antihypertensive therapy. Keywords: Purple sweet potato, anthocyanin, antihypertensive, nasal spray, and ACE inhibitor.