<![CDATA[Escherichia coli is one of the main causes of diarrhea; therefore, alternative antibacterial agents derived from natural materials are needed. Roselle flowers (Hibiscus sabdariffa L.) and cinnamon bark (Cinnamomum burmannii) are known to possess antibacterial activity through different mechanisms of action. This study aimed to determine and compare the antibacterial activity of 30% roselle flower extract, 10% cinnamon bark extract, and their combination against Escherichia coli. The theoretical basis of this study was the flavonoid content in roselle and the cinnamaldehyde and eugenol compounds in cinnamon as antibacterial agents. This research was an experimental study using the disk diffusion method with three treatment groups and one negative control group. The observed parameter was the diameter of the inhibition zone after 24 hours of incubation at 37°C. The results showed that all treatment groups produced inhibition zones in the moderate category, while the negative control did not produce any inhibition zone. Statistical analysis using the Kruskal Wallis test showed a significant difference in antibacterial activity among the groups (Asymp.Sig = 0.000008). Further analysis using the Mann Whitney test showed that the combination extract had the highest antibacterial activity.]]>
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