Jurnal Kedokteran Ibnu Nafis
Vol. 15 No. 1 (2026): Juni 2026

PENGARUH MINUMAN KOMBUCHA SALAK SIDEMPUAN TERHADAP KADAR HDL DAN LDL PADA TIKUS DIET TINGGI LEMAK

Salsabila Khalda (Universitas Muhammadiyah Sumatera Utara)
Isra Thristy (Universitas Muhammadiyah Sumatera Utara)



Article Info

Publish Date
06 Jun 2026

Abstract

Dyslipidemia is a metabolic disorder characterized by continuous alterations in plasma lipid levels. Kombucha, a fermented beverage produced from sweetened tea using SCOBY, has been reported to lower cholesterol levels. Research on kombucha continues to expand, particularly regarding the use of non-tea substrates for fermentation, such as salak fruit. This study aimed to analyze the effect of Sidempuan salak kombucha on HDL and LDL levels in male rats (Rattus norvegicus) induced with a high-fat diet. A true experimental method with a posttest-only control group design was employed, involving 32 rats divided into four groups: KN (standard feed for 6 weeks), K− (standard feed + high-fat diet for 6 weeks), P1 (standard feed + high-fat diet + 2.7 ml/day Sidempuan salak kombucha for 6 weeks), and P2 (standard feed + high-fat diet + 5.4 ml/day Sidempuan salak kombucha for 6 weeks). The collected data were analyzed using a One-Way ANOVA test. The results showed no significant differences in HDL and LDL levels among the four groups (p > 0.05). In conclusion, the administration of Sidempuan salak kombucha did not produce a significant effect on HDL and LDL levels in male rats induced with a high-fat diet.

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Journal Info

Abbrev

ibnunafis

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Description

Jurnal Kedokteran Ibnu Nafis merupakan jurnal yang diterbitkan oleh Fakultas Kedokteran Universitas Islam Sumatera Utara. Jurnal ini diterbitkan setiap 6 bulan yaitu pada bulan Juni dan Desember yang menerima dan menerbitkan artikel penelitian, tinjauan pustaka dan laporan kasus di bidang kedokteran ...