<![CDATA[This study aimed to evaluate the effects of orally administered forest bee honey (Apis dorsata) on hematological profiles and blood glucose levels in mice (Mus musculus) using a true experimental pretest–posttest control group design. The study was conducted over 14 days, including 7 days of acclimatization followed by 7 days of treatment, with one control group and two treatment groups receiving different honey–water ratios at a dose of 0.25 mL per mouse per day. Hematological parameters (including erythrocytes, leukocytes, hemoglobin, hematocrit, platelets, and erythrocyte indices) were measured using a hematology analyzer, while blood glucose levels were assessed using a glucometer before and after treatment. The results showed variable and inconsistent changes in hematological parameters among treatment groups compared with the control group, with several values falling outside normal physiological ranges. This suggests a considerable influence of technical factors such as sample quality, equipment limitations, and handling-related stress. Blood glucose concentrations in both honey-treated groups generally remained within physiological limits and did not exhibit marked hyperglycemic or clearly hypoglycemic effects. However, incomplete baseline data for all animals limited the precise interpretation of treatment-related changes. Overall, oral administration of forest bee honey under the present conditions did not demonstrate a clear and consistent effect on hematological profiles or glucose regulation in mice. These findings indicate the need for further studies with larger sample sizes, complete baseline measurements, and stricter control of experimental and environmental variables to better clarify the hematological and metabolic effects of forest bee honey.]]>
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