<![CDATA[Epigallocatechin gallate (EGCG), a major polyphenolic compound in green tea, possesses strong antioxidant properties that may counteract oxidative stress–induced liver damage caused by cigarette smoke exposure. This study aimed to analyze hepatic histopathological changes in mice exposed to cigarette smoke following green tea administration. The study employed a true experimental design with a post-test-only control group approach. Twenty-five male Mus musculus mice aged 12 weeks and weighing 20–25 g were used as experimental animals and randomly assigned into five groups, with five mice in each group. The treatment groups (T1, T2, and T3) received green tea formulation at doses of 20, 40, and 60 mg/kg body weight, respectively. The negative control group (C−) was not exposed to cigarette smoke and received 0.5 mL of 1% Na-CMC, whereas the positive control group (C+) was exposed to cigarette smoke and administered 0.5 mL of 1% Na-CMC. The positive control group (C+) showed significant histopathological damage compared with the negative control group (p < 0.05), with mean scores of 2.63 ± 0.23 for hepatic vascular congestion, 6.43 ± 0.55 for hepatocyte necrosis, and 3.61 ± 0.36 for hepatocyte degeneration. Green tea extract reduced tissue damage in a dose-dependent manner, with the highest dose (T3; 60 mg/kg BW) providing optimal protection, as indicated by scores of 0.32 ± 0.15, 1.82 ± 0.37, and 1.14 ± 0.33, respectively, which were comparable to those of the negative control group (p > 0.05). Green tea formulation demonstrated effective hepatoprotective activity against cigarette smoke–induced liver injury, with maximal protective effects observed at a dose of 60 mg/kg BW.]]>
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