Association between D-Dimer and CRP Levels in Confirmed COVID-19 Patients with Diabetes Mellitus Comorbidity at Jakarta Hajj Hospital

Atna Permana (Medical Laboratory Technology, Faculty of Health MH Thamrin University, Indonesia)
Adik Purnama (Department of Laboratory, Haji Hospital Jakarta, Indonesia)
Warida Warida (Medical Laboratory Technology, Poltekkes Kemenkes Jakarta III, Indonesia.)
Haitami Haitami (Medical Laboratory Technology, Poltekkes Kemenkes Banjarmasin, Indonesia.)

Medical Laboratory Technology Journal
Vol. 12 No. 1 (2026): June

COVID-19 may induce systemic inflammation and coagulation abnormalities, particularly in patients with Diabetes Mellitus (DM). C-Reactive Protein (CRP) is an inflammatory biomarker, while D-Dimer reflects coagulation activation and fibrinolysis. In COVID-19 patients with DM, both biomarkers may increase due to chronic inflammation, hyperglycemia, endothelial dysfunction, and a prothrombotic state. This study aimed to analyze the correlation between D-Dimer and CRP levels in confirmed COVID-19 patients with comorbid Diabetes Mellitus at Haji Hospital Jakarta. This was an observational analytic study with a cross-sectional design using secondary data from medical records of hospitalized COVID-19 patients with DM at Haji Hospital Jakarta from June to September 2021. Total sampling was applied. A total of 80 patients who met the inclusion and exclusion criteria were included in the analysis. The main variables were D-Dimer and CRP levels. Descriptive analysis was used to describe subject characteristics, while the Spearman correlation test was used to assess the correlation between D-Dimer and CRP because the data were not normally distributed. Among 80 subjects, 44 patients (55.0%) were male, and 36 patients (45.0%) were female. The mean age was 55.76 ± 12.28 years, and the mean random blood glucose level was 303.75 ± 70.56 mg/dL. The mean D-Dimer level was 0.96 ± 1.51 µg/mL with a median of 0.50 µg/mL, while the mean CRP level was 58.48 ± 28.59 mg/L with a median of 55.0 mg/L. Elevated D-Dimer levels were found in 41 patients (51.3%), while all subjects (100%) had elevated CRP levels. Spearman correlation analysis showed no significant correlation between D-Dimer and CRP levels (r_s = -0.057; p = 0.618). There was no significant correlation between D-Dimer and CRP levels in COVID-19 patients with comorbid Diabetes Mellitus at Haji Hospital Jakarta. However, both biomarkers may still provide complementary information regarding inflammatory and coagulation status abnormalities in COVID-19 patients with DM.