Chronic kidney failure is a progressive disease that causes a permanent decline in kidney function so that patients need long-term hemodialysis therapy. Hemodialysis that is carried out continuously can have physical, psychological, social, and emotional impacts that affect the patient's quality of life. This study aims to determine the relationship between long-term hemodialysis therapy and the quality of life of chronic kidney failure patients at Prof. Dr. H. Aloei Saboe Hospital, Gorontalo City. This study uses a quantitative method with a cross sectional design. The population in this study is all patients with chronic kidney failure who undergo hemodialysis therapy at Prof. Dr. H. Aloei Saboe Hospital as many as 83 patients. The research sample amounted to 46 respondents who were taken using purposive sampling techniques. The instrument used was the KDQOL-SF 36 questionnaire to measure the patient's quality of life. Data analysis used the Fisher's Exact Test. The results showed that most of the respondents underwent hemodialysis >12 months, 35 respondents (76.1%), while 11 respondents (23.9%)
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