Hypertension has become a chronic disease known as the silent killer because it often does not show symptoms but can cause serious complications such as stroke, heart disease, and kidney failure. According to WHO, hypertension is one of the leading causes of death worldwide and its prevalence continues to rise. Sleep disturbances can increase sympathetic nervous system activity and stress hormones, which impact blood pressure elevation. Depression is characterized by prolonged feelings of sadness, loss of interest, and decreased energy. Physiologically, depression can increase stress hormones and cause autonomic nervous system imbalance, leading to elevated blood pressure. To determine the relationship between sleep pattern disturbances and depression levels with blood pressure in hypertensive patients in the outpatient department of RS Permata Medika Semarang. Quantitative research with a correlational design using a cross-sectional approach. The sampling technique used was consecutive sampling with a sample size of 79 respondents. The instruments used are the PSQI questionnaire for sleep pattern disturbances and the DASS-42 for depression levels. Ethics test no 03/EC-LPPM/UWHS/II-2026. Data analysis used the Spearman Rank test. The research results show that there is a significant relationship between sleep pattern disturbances and blood pressure in hypertensive patients (p=0.000; rho=0.826). Respondents with poor sleep patterns mostly have high blood pressure, indicating a very strong and positive relationship, where the worse the sleep pattern, the more uncontrolled the blood pressure tends to be. Additionally, there is a significant relationship between the level of depression and blood pressure (p=0.000; rho=0.808). Respondents with severe and very severe depression mostly have high blood pressure, which means that the higher the level of depression, the more the blood pressure increases or becomes uncontrolled. There is a relationship between sleep pattern disturbances and depression levels with blood pressure in hypertensive patients in the outpatient department of Permata Medika Hospital Semarang.
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