<![CDATA[Insulin resistance is a condition characterized by decreased cellular sensitivity to insulin, leading to impaired glucose metabolism and contributing to the development of type 2 diabetes mellitus. The development of plant-based therapies has become an increasingly attractive alternative, one of which is Moringa oleifera, known to contain various bioactive compounds with potential antidiabetic properties. This study aimed to analyze the potential of Moringa oleifera against insulin resistance using network pharmacology and molecular docking approaches. The study was conducted through active compound identification, protein target prediction, protein–protein interaction (PPI) analysis, hub gene identification, and molecular docking simulations using the mTOR receptor (PDB ID: 4DRI). The results revealed 11 overlapping genes between compound-related targets and insulin resistance-associated targets, with mTOR identified as the primary hub gene based on network topology analysis. Docking validation showed an RMSD value of 0.525 Å, indicating that the docking protocol used was valid. Molecular docking results demonstrated that lupeol exhibited the best binding affinity among the tested compounds with a binding energy value of −8.46 kcal/mol and showed interactions with amino acid residues within the receptor binding site. These findings suggest that the active compounds of Moringa oleifera have the potential to modulate protein targets involved in insulin resistance and may serve as promising candidates for insulin resistance therapy through an insilico approach.]]>
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