<![CDATA[Background: Oral cancer ranks as the 16th most common malignancy, with a disproportionately higher incidence in Asia. The 5-year overall survival (OS) of oral cancer shows differences in many countries. In Indonesia, many patients present at advanced stages, making adequate surgery followed by appropriate adjuvant therapy crucial for optimal outcomes. This study aims to evaluate the factors affecting OS, focusing on the comparison between adjuvant radiotherapy and chemoradiotherapy in oral cancer patients at Dharmais Cancer Hospital.Method: A retrospective study was conducted on 51 samples collected from patients’ medical record started in January 2017 to January 2024, and patients were followed up by phone. Overall survival was calculated with Kaplan-Meier analysis, and prognostic factors were analyzed using the Cox-Regression.Result: The 5-year OS rate for oral cancer patients was 58.1%, while patients who underwent adjuvant radiotherapy and chemoradiotherapy had rates of 51% and 40%, respectively (p-value 0.35); this difference was not statistically significant. Cox-regression analysis showed that comorbidities (HR, 2.8; 95 CI, 1.05—7.4; P = 0.04), tumor grade (HR, 11.3; 95% CI, 1.88—67.94; P = 0.008), and stage (HR, 0.11; 95% CI, 0.01—0.9; P = 0.04) were associated with OS in oral cancer patients. Conclusion: Five-year OS of oral cancer patients in Dharmais Cancer Hospital was 58.1%. Patients who received adjuvant radiotherapy tended to have better OS than those who received adjuvant chemoradiotherapy, although the difference was not statistically significant. Additionally, comorbidities, tumor grade, and stage were found to be significantly associated with OS in oral cancer patients.]]>
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