<![CDATA[Background: Cancer-related fatigue is a significant concern for breast cancer patients undergoing chemotherapy, yet Indonesia lacks a culturally validated tool to assess. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Fatige-12 (EORTC QLQ-FA12), which measures physical, emotional, and cognitive fatigue, is available only in English. This study aims to evaluate the validity and reliability of the Indonesian version of the EORTC QLQ-FA12.Methods: A cross-sectional methodological study applied forward-backward translation following Beaton’s guidelines. Pretesting and validation involved 30 and 70 patients, respectively. Psychometric evaluation included content validity, internal consistency, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). Results: The scale showed strong content validity index (CVI = 0.917) and internal consistency (alpha = 0.905). Although EFA suggested statistical clustering of items, CFA supported the theoretical multidimensional structure of the original instrument. Model fit indices were acceptable (Goodness-of-Fit Index (GFI) = 0.952, Comparative Fit Index (CFI) = 0.930, Tucker Lewis Index (TLI) = 0.904, Standardized Root Mean Square Residual (SRMR) = 0.056), while Root Mean Square Error of Approximation (RMSEA) = 0.098 indicated moderate approximation error. Factor loading ranged from 0.23 to 0.91.Conclusions: The Indonesian EORTC QLQ-FA12 demonstrates satisfactory reliability and acceptable construct validity, preserving the multidimensional fatigue framework. The instrument is suitable for clinical and research assessment of cancer-related fatigue in Indonesian breast cancer patients]]>
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