<![CDATA[Background: Stress is a psychological condition that has the potential to affect the immune system, including the leukocyte count and erythrocyte sedimentation rate. Various reasons might induce stress in female students, including physical ailments, interpersonal interactions, academic pressures, and environmental conditions. Objective: This study aims to analyze the difference in leukocyte count and erythrocyte sedimentation rate in female students with different stress levels at the Faculty of Health Sciences, Setia Budi University. Methods: This study was an observational quantitative research with a cross-sectional approach which was carried out in October 2024-April 2025 with a total of 68 female students selected by purposive sampling. Stress measurement using Student Stress Inventory questionnaires. Leukocyte count was calculated using a hematology analyzer, and erythrocyte sedimentation rate was examined using the Westergren method on EDTA venous blood samples. Results: The data was analysed with Independent-t Test. The analysis's findings demonstrated that the high-stress group had more leukocytes than the low-stress group (p=0.004). The high-stress group had a higher erythrocyte sedimentation rate than the low-stress group (p=0.001). Conclusion: There is a significant difference in leukocyte count and the erythrocyte sedimentation rate between female students with different levels of stress.]]>
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