Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.)
Vol. 5 No. 1 (2026): Indones. J. Chem. Stud. June 2026

Cytotoxic Evaluation of Medicinal Plants used by Suku Anak Dalam Community in Jambi Province Using the Brine Shrimp Lethality Test

Santi Perawati (Department of Pharmacy, Universitas Jambi, Jambi 36361, Indonesia)
Nurul Kamilah Sadli (1Department of Pharmacy, Universitas Jambi, Jambi 36361, Indonesia)
Marizki Pondawinata (Department of Pharmacy, Universitas Jambi, Jambi 36361, Indonesia)
Rina Oktaria (Department of Nursing, Universitas Jambi, Jambi 36361, Indonesia)
Lili Andriani (Chemistry Doctoral Program, Universitas Andalas, 25163, Padang 25163, Indonesia)
Diah Kusumawati (Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Harapan Ibu, Jambi 36122, Indonesia)
Evelin Sabatini Sinaga (Department of Pharmacy, Universitas Jambi, Jambi 36361, Indonesia)
Fauziyah (Department of Pharmacy, Universitas Jambi, Jambi 36361, Indonesia)



Article Info

Publish Date
22 Jun 2026

Abstract

Cancer remains a major global health challenge, and the search for effective therapeutic agents continues. Natural products, including traditional medicinal plants used by the Suku Anak Dalam (SAD) community in Jambi, offer promising sources of bioactive compounds. This study investigated the cytotoxic potential of ten SAD medicinal plants extracted through a decoction method. Phytochemical screening revealed the presence of alkaloids, flavonoids, and saponins. Cytotoxicity was assessed using the Brine Shrimp Lethality Test (BSLT) at concentrations of 50, 100, 500, and 1000 ppm. All plant extracts exhibited toxic-level cytotoxicity, which correlated with their secondary metabolite profiles and their inhibitory effects on Artemia salina Leach larvae. The LC₅₀ values ranged from 150 to 400 ppm, indicating that these traditional medicinal plants possess notable cytotoxic activity. These findings support the potential of SAD ethnomedicinal plants as candidates for further investigation in anticancer research.

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Journal Info

Abbrev

ijcs

Publisher

Subject

Chemistry

Description

Indonesian Journal of Chemical Studies (IJCS) is a peer-reviewed, open-access journal that publishes original research articles, review articles, as well as short communication in all areas of basic and applied chemistry. IJCS was managed & published by the Indonesian Scholar Society. This journal ...