<![CDATA[BackgroundHistological grade and MMP-9 expression are prognostic factors in invasive breast carcinoma, nevertheless thecorrelation between both prognostic factors is still debatable. The aim of this study was to determine therelationship between expression of MMP-9 and histological grade and to evaluate which characteristic factor ofthe histological grade is dominant to MMP-9 expression in invasive breast carcinoma.MethodsThis study was carried out using a cross sectional analytical method. The samples were paraffin blocks frominvasive carcinoma of no special type grade I, II, and III at Pathology Anatomy Department UdayanaUniversity/RSUP Sanglah Denpasar from 1st January 2013 to 31st July 2016. Histopathologically re-diagnosiswas conducted to get the eligible samples and obtained 47 samples, consisted of 7 samples grade I, 18samples grade II, and 22 samples grade III. Immunohistochemistry of the MMP-9 was done and the result wascorrelated to histological grade and characteristic factor of histological grade.ResultsThe study results showed high expression of MMP-9 2.1% (n=1) in grade I, 19.2% (n=9) in grade II, and 36.2%(n=17) in grade III. Chi-square test analysis showed there was a significant correlation between tumor gradeand MMP-9 expression (p=0,010). The logistic regression test showed the mitotic counting was statisticallysignificant dominant factor (p=0.012) determining MMP-9 expression, whereas tubular formation and nuclearpleomorfia were not statistically significant (p>0.05).ConclusionHigh expression of MMP-9 was correlated with high histological grade, which also indicated worse prognosis.MMP-9 testing is an important examination to determine the level of tumour aggresive-ness and plan theeffective therapies]]>
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