<![CDATA[Background: Tuberculosis (TB) remains a major global public health challenge. Indonesia ranks second globally in TB burden, accounting for 10% of total cases. Treatment dropout is a significant barrier to TB control, contributing to drug resistance, relapse, and mortality. This study aimed to analyze factors associated with TB treatment dropout at primary health centers in Rantau Prapat City in 2026. Method: This analytic survey used a cross-sectional design. A total of 186 TB patients were selected using purposive sampling from five primary health centers in Rantau Prapat City. Data were collected through structured interviews using a validated questionnaire covering sociodemographic characteristics, alcohol consumption, medication adherence, family support as a treatment supervisor, and health worker support. Bivariate analysis used the Chi-square test, and multivariate analysis used logistic regression (α = 0.05). Results: The majority of respondents were aged 37–45 years (49.5%) and male (56.5%). Alcohol consumption was not significantly associated with dropout (p > 0.05). Significant associations were found between medication adherence and dropout (p < 0.001), family support and dropout (p < 0.001), and health worker support and dropout (p < 0.001). Multivariate analysis identified health worker support as the most dominant factor (OR = 32.88; p < 0.001), indicating that patients with high health worker support had substantially greater odds of treatment completion. Conclusion: Medication adherence, family support, and health worker support are significantly associated with TB treatment dropout. Health worker support was the most dominant factor. Strengthening patient education, family involvement, and health worker engagement is essential to reduce dropout rates.]]>
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