<![CDATA[In recent years, innovative drug-delivery systems have been considered one of the most crucial techniques for enhancing cancer treatment. In this study, F127, a thermal-sensitive polymer, was utilized to conjugate to the surface of HMSN, and subsequently, the carriers were loaded with Dox. The obtained product was characterized by a series of experiments, including TEM, FT-IR, TGA, XRD, and zeta potential. The HMSN-F127 carrier system was successfully synthesized with a size of 152.9 ± 0.9 nm. Furthermore, the SEM results revealed that the pores were located within the material. The zeta potential was determined to be -4.03 ± 0.15 mV, with a corresponding surface area of 168.4 m2/g. The efficiency and drug loading capacity of HMSN-F127 were found to be higher than those of naked HMSN with DLE and DLC values of 72.08 ± 0.09 % and 11.09 ± 0.01 %, respectively. In particular, Dox was well controlled by HMSN-F127. At concentrations ranging from 0 - 250 μg/ml, HMSN-F127 was not toxic to HCC J5 cells. The findings demonstrate that the HMSN-F127 system provides an effective platform for enhancing drug loading and achieving controlled drug release, thereby highlighting its potential for improved anticancer drug delivery and future development of stimuli-responsive nanocarriers.]]>
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