<![CDATA[Background: Pain is an unpleasant sensation that can range from mild to severe, causing discomfort and potentially disturbing daily activities. Therefore, pain management and treatment are necessary. Kumis kucing (Orthosiphon stamineus) is a traditional medicinal plant known to contain flavonoids with anti‑inflammatory and analgesic properties that can help alleviate pain. Objective: This study aimed to investigate the analgesic activity and determine the effective dose of Orthosiphon stamineus extract. Methods: The design of this study was a true experimental post‑test‑only randomized controlled group. Pain was induced using a 1% acetic acid intraperitoneal injection to evoke the writhing reflex in mice. The writhing reflex was observed every 10 minutes for 1 hour, and the data were analyzed using one‑way ANOVA followed by a post‑hoc test. Results: The results revealed significant differences in analgesic activity between the P1 and P3 groups, as well as between the P2 and P3 groups (p < 0.05), indicating that the kumis kucing extract at a dose of 0.24 mg/gBW effectively reduced pain, as demonstrated by a decreased total number of writhing reflexes. The pain protection percentage at the 0.24 mg/gBW dose was 48.75%. Conclusion: Kumis kucing extract has significant analgesic activity, with the most effective dose being 0.24 mg/gBW.]]>
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