Muhammadiyah Medical Journal
Vol. 7 No. 1 (2026): Muhammadiyah Medical Journal (MMJ)

Effectiveness of Ethanol Extract of Cloves (Syzygium aromaticum) in Inhibiting the Growth of Streptococcus pneumoniae

Dian Shavitri Ariani Rusmana (Medical Study Program, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta)
Rike Syahniar (Department of Microbiology, Faculty of Medicine and Health, Universitas Muhammadiyah Jakartammadiyah Jakarta)
Rina Nurbani (Department of Microbiology, Faculty of Medicine and Health, Universitas Muhammadiyah Jakartammadiyah Jakarta)
Muhammad Dwi Putra (Department of Microbiology, Faculty of Medicine and Health, Universitas Muhammadiyah Jakartammadiyah Jakarta)



Article Info

Publish Date
30 Mar 2026

Abstract

Background: Pneumonia is a lung disease caused by Streptococcus pneumoniae. Streptococcus pneumoniae is the leading cause of death in children and the elderly. The content of clove flower ethanol extract shows bacteriostatic activity with a mechanism that damages bacterial cell walls. Eugenol content is known to play an important role in inhibiting the growth of S. pneumoniae. Purposes: This study aims to determine the effectiveness of ethanol extract of clove flowers (Syzygium aromaticum) in inhibiting the growth of Streptococcus pneumoniae. Methods: This research method uses an experimental method. The sample used was Streptococcus pneumoniae ATCC 49619. Ethanol extract of clove flowers that had been diluted with concentrations of 20%, 40%, 60%, 80% and 100% was tested for antibacterial properties using the Kirby-Bauer Agar Diffusion Test method in inhibiting Streptococcus pneumoniae. Results: The results of the antibacterial test of clove flower ethanol extract showed effectiveness in the form of an inhibition zone for the growth of Streptococcus pneumoniae with an optimal concentration of 80%, an inhibition zone size of 19.50 mm which is included in strong antibacterial, and there is a bioactive compound eugenol which is antibacterial. Conclusion: Ethanol extract of cloves (Syzygium aromaticum) has been effective in inhibiting the growth of Streptococcus pneumoniae.

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Journal Info

Abbrev

MMJ

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Description

Muhammadiyah Medical Journal (MMJ) Faculty of Medicine and Health is an international journal based on scientific research. The journal is published 2 (two) times in 1 year, March and September. Muhammadiyah Medical Journal Faculty of Medicine and Health invites the lecturers, practitioners and ...