Background: Health websites can enhance health literacy among patients with chronic kidney disease. Patients' satisfaction with health websites is related to website usability and their perception of the website's information, which can be assessed using the System Usability Scale questionnaire. Objective: Assess the level of satisfaction of chronic kidney disease patients towards health websites, using the System Usability Scale questionnaire that is specifically adapted for website assessment. Methods: We conducted content and construct validity tests, followed by a reliability test using Cronbach's alpha. Subsequently, a correlation study was conducted to assess the System Usability Scale questionnaire's ability to measure website quality, with particular emphasis on user satisfaction. Results: Nine panelists conducted a content validity assessment. In addition, 35 patients with chronic kidney disease participated in the construct validity, reliability, and patient satisfaction tests. Regarding content validity, the ratio was ≥ 0.78 (valid), and the content validity index was > 0.89 (appropriate and relevant). The questionnaire demonstrated validity (construct validity > 0.325) and reliability (Cronbach's alpha 0.741). Furthermore, there was a strong correlation between the SUS adjective scores and direct patient satisfaction assessments (coefficient interval 0.767). Finally, patient satisfaction with health websites varied by website type (p<0.001). Conclusions: The System Usability Scale questionnaire in Indonesian was valid and reliable for assessing health websites, and can be used to assess patient satisfaction with health-related websites. Most patients have a good level of satisfaction, and the type of website accessed affects satisfaction among chronic kidney disease patients.
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