<![CDATA[The rapid development of genomic technology has heightened the urgency to address vulnerabilities in centralized systems managing sensitive human genetic data. This study proposes a decentralized system integrating blockchain and IPFS to enhance data security, integrity, and accessibility. Blockchain ensures immutable audit trails and dynamic access control via smart contracts, while IPFS provides scalable off-chain storage using cryptographic hashes (CIDs). The hybrid design separates raw data storage (encrypted via homomorphic encryption) on IPFS from access management on the Ethereum blockchain. A user interface built with React.js and Web3.js enables encrypted data uploads, role-based access requests, and real-time audit monitoring, complying with GDPR/HIPAA standards. Testing demonstrated the system’s effectiveness in preventing unauthorized access and ensuring data traceability. Challenges such as energy efficiency and regulatory compliance were addressed through sharding, layer-2 protocols, and selective data deletion mechanisms. This framework supports secure cross-institutional collaboration in genomic research, promoting public participation and accelerating biomedical innovation. Future work will focus on optimizing computational efficiency and expanding datasets.]]>
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