Non-Communicable disease (NCDs) continue to be the focus of health throughout the world. Risk factors such as smoking habits, examined by the increasing number of cigarettes smoked everyday and duration of smoking, can lead to elevated levels of total cholesterol due to the cumulative effects of nicotine and free radicals. This study aims to determine the correlation between the number and duration of smoking with total cholesterol levels in active smokers. Methods this research used observational analytical method with cross sectional design, conducted from February-March 2024. 96 respondents smokers were selected as the research sample using purposive sampling technique, and total cholesterol examination was conducted using the POCT method. Data analysis is cholesterol performed using chi-square test. Result shows that respondents who consumed > 20 cigarettes had high total cholesterol levels as many as 10 people (38.4%) and respondents who consumed cigarettes > 10 years had high total cholesterol levels as many as 12 people (18.5%). Conclusion, there is a correlation between the number of cigarettes consumed and total cholesterol levels and there is no correlation between the duration of smoking and total cholesterol levels ini active smokers in South Denpasar Areas
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