<![CDATA[Accurate diagnosis of papulosquamous skin diseases such as Psoriasis (PS), Lichen Planus (LP), Pityriasis Rosea (PR), and Pityriasis Rubra Pilaris(PRP) is challenging due to their visually similar features, particularly during healing stages. This study presents an optimized deep learning framework to improve diagnostic accuracy and interpretability. A dataset of 3,120 DermsNetZ images was used, with preprocessing through contrast limited adaptive histogram equalization(CLAHE) to enhance lesion visibility. Pretrained convolutional neural networks (CNNs) including MobileNetV2, InceptionV3, NASNet, and hybrid models were evaluated using accuracy, precision, recall, and F1-score. Among these, MobileNetV2 combined with gradient-class activation mapping (Grad-CAM) achieved the best results, delivering 94% accuracy, 95% precision, and strong F1-scores, while offering explainable artificial intelligence (AI) through lesion localization. To translate these results into practice, the SkinSense Detection App was developed, integrating with transfer learning, class balancing, augmentation, and Grad-CAM visualization within a user-friendly interface. The app also incorporates a large language model (LLM-powered) chatbot for real-time, personalized feedback. With an overall success rate of 98.08% and user ratings between 4.6–4.8/5, the system demonstrates high reliability and accessibility. This study highlights the value of interpretable deep learning in dermatology, bridging technical accuracy with clinical usability and offering scope for expansion to larger datasets and diverse skin conditions.]]>
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