Dentika Dental Journal
Vol. 29 No. 1 (2026): Dentika: Dental Journal

Biological Markers to Detect Periodontal Severity in Postmenopausal Women: A Systematic Review

Megawati (Faculty of Dentistry, Universitas Sumatera Utara)
Pitu Wulandari (Faculty of Dentistry, Universitas Sumatera Utara)
Lutfi Putra Perdana (Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan)

Article Info

Publish Date
29 Jul 2026

Abstract

Periodontal disease is a significant health concern, particularly in postmenopausal women due to hormonal changes affecting immune response and bone metabolism. This study reviews non-invasive biomarkers for detecting and monitoring disease severity through a literature search in PubMed, Cochrane Library, and Science Direct (2015–2025). Five studies found that biomarkers such as salivary cytokines, calcium, estradiol, calprotectin, and serum markers are significantly associated with periodontal clinical parameters. These biomarkers show potential for early detection and personalized management, although further research is still needed.

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Journal Info
Dentika Dental Journal
Website

Abbrev

dentika

Publisher

Universitas Sumatera Utara

Subject

Dentistry

Description

d e n t i k a DENTAL JOURNAL is one of the journals managed by TALENTA Universitas Sumatera Utara which first published in 2015. This is an online scientific journal that publishes articles and scientific work from Researches, Case Reports and Literature Reviews in Dentistry and Dental Science. The ...