Purpose: This study examines the mediating role of Islamic entrepreneurship in the relationship between Islamic organizational culture and asatidzah well-being in modern pesantren. Methodology/approach: This study used a quantitative associative approach. Primary data were collected through a structured questionnaire distributed to 385 asatidzah in modern pesantren in Banten Province. The respondents were selected using multistage probability sampling, with criteria including a minimum of two years of teaching experience. The data were analyzed using descriptive statistics and structural equation modeling to examine the direct and indirect relationships among Islamic organizational culture, Islamic entrepreneurship, and asatidzah well-being. Findings: The results show that Islamic organizational culture positively affects asatidzah well-being and Islamic entrepreneurship. Islamic entrepreneurship also positively affects asatidzah well-being and mediates the relationship between Islamic organizational culture and asatidzah well-being. These findings indicate that strengthening organizational culture and Islamic entrepreneurship can support better well-being among asatidzah in modern pesantren. Practical and Theoretical contribution/Originality: This study enriches Islamic management literature by positioning Islamic entrepreneurship as a mediating variable and offers practical insight for strengthening institutional culture and teacher well-being. Research Limitation: This study is limited to modern pesantren in Banten Province, so the findings may not fully represent other contexts.
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