<![CDATA[Background: Awareness of Systemic Lupus Erythematosus (SLE) is critically low among Indonesian adolescents, despite clinical evidence showing that approximately 52% of pediatric cases occur between the ages of 11 and 15. This study evaluated the effectiveness of a health education seminar conducted during a community service program entitled “LUPUS CERDAS: Cekatan, Energik, Responsif, dan Sadar Sehat” in improving health literacy regarding SLE, photoprotection, and physical activity among junior high school students. Methods: A quasi-experimental one-group pre-test/post-test design was conducted at SMPN 2 Jatinangor, involving 35 students from Grades 7 to 9. Data were collected using a validated 20-item multiple-choice questionnaire and a thematic qualitative feedback form. Results: There was a statistically significant improvement in knowledge scores, increasing from a mean of 72.29 ± 12.97 to 81.71 ± 15.34 (p < 0.001), representing a 13.04% gain from the baseline. Qualitatively, 57.1% of students identified the pathology of Lupus as the most engaging topic due to its novelty, while 85.7% rated the visual educational aids as "Very Helpful." Notably, the study identified a "Silent Knowledge Gap," with 28.6% of participants remaining uncertain about their family medical history regarding autoimmune symptoms. Conclusions: Targeted community service interventions are powerful tools in enhancing adolescent health literacy. By providing students with an evidencebased framework for understanding autoimmune triggers, these programs increase awareness regarding early recognition and family health communication. Future outreach should prioritize the integration of mental health and lifestyle management into school-based health curriculum.]]>
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