The prevalence of Chronic Kidney Disease (CKD) is increasing globally, including among adolescents. Limited knowledge about CKD prevention may predispose to unhealthy lifestyle behaviors that increase the risk of kidney damage. This study aimed to examine the effect of Kidney Risk Education (KREN), an audiovisual edutainment-based intervention on adolescents’ knowledge on CKD prevention at SMPN 21 Central Bengkulu, Indonesia. A pre-experimental one group pretest-posttest design was conducted involving 81 students. Knowledge was assessed using validated and reliable questionnaire administered before and after the intervention. KREN was delivered through audiovisual edutainment focusing on CKD risk factors, prevention strategies, and healthy lifestyle behaviors. Data were analyzed using the Wilcoxon signed-rank test. The results showed a statistically significant increase on students’ knowledge scores after the intervention (p = 0.0001), indicating that KREN effectively enhanced adolescents’ knowledge of CKD prevention. Audiovisual-based health education can serve as a practical and scalable health promotion strategy in school settings to support early prevention of chronic kidney disease. However, further studies with control groups are needed to strengthen the validity of these findings.
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