<![CDATA[Clinical Decision Support Systems (CDSS) are increasingly used to support clinical reasoning, patient management, and healthcare quality. However, their successful implementation depends not only on technical performance but also on acceptance among healthcare workers. This study aimed to analyze the effect of perceived usefulness, trust, and digital literacy on the acceptance of CDSS among healthcare workers. A quantitative analytical study with a cross-sectional design was conducted among healthcare workers involved in clinical services, including physicians, nurses, and midwives. Data were collected using a structured questionnaire measuring perceived usefulness, trust, digital literacy, and CDSS acceptance. The data were analyzed using univariate analysis and bivariate analysis with Fisher’s Exact Test and odds ratio estimation. The findings showed that most respondents had good perceived usefulness, good digital literacy, and good acceptance of CDSS, while trust was also generally positive but had a larger moderate proportion compared with other variables. Perceived usefulness significantly influenced CDSS acceptance, with respondents who perceived CDSS as useful being more likely to show good acceptance. Trust was also significantly associated with acceptance, as all respondents with good trust demonstrated good acceptance of CDSS. Digital literacy significantly influenced acceptance as well, indicating that healthcare workers with stronger digital capability were more prepared to accept CDSS in clinical practice. These findings suggest that improving CDSS acceptance requires clear practical benefits, reliable and transparent system performance, and adequate digital readiness supported by training and technical assistance.]]>
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