Journal of Pharmaceutical and Sciences.
JPS Volume 9 Nomor 3 (2026)

Uji Efektivitas Anti-Aging Ekstrak Bunga Kembang Sepatu (Hibiscus rosa-sinensis L.) Dalam Sediaan Masker Clay

Tetty Noverita Khairani (Institut Kesehatan Helvetia)
Khairani Fitri (Institut Kesehatan Helvetia)
Luthvia Luthvia (Institut Kesehatan Helvetia)
Leny Leny (Institut Kesehatan Helvetia)
Faizah Rahman (Institut Kesehatan Helvetia)



Article Info

Publish Date
23 Jul 2026

Abstract

Introduction: Skin aging is a natural degenerative process triggered by internal and external factors, particularly oxidative stress caused by free radicals. Hibiscus rosa-sinensis L. contains flavonoid and anthocyanin compounds which have potential as natural antioxidants to inhibit the skin aging process. Objective: This study aimed to formulate and evaluate a clay mask containing ethanol extract of Hibiscus rosa-sinensis flowers and to test its anti-aging effectiveness on skin condition parameters. Methods: This experimental study involved the preparation of clay masks with three variations of extract concentrations: 2.5% (F1), 5% (F2), and 10% (F3). Physical quality evaluations included homogeneity, pH, stability, drying time, emulsion type, and irritation tests. Anti-aging effectiveness testing was conducted on 15 female volunteers aged 35–60 years using a skin analyzer over 4 weeks with once-weekly application. Measured parameters included moisture, evenness, pore size, spots, and wrinkles. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test. Results: All formulas met the physical quality requirements with pH values of 6.4–6.7, homogeneous, stable during 12 weeks of storage, and caused no irritation. Formula III (10% concentration) demonstrated the best anti-aging effectiveness with increases in moisture content of 67.5%, decreases in roughness of 42.3%, decreases in pore size of 30.9%, decreases in spots of 32.4%, and decreases in wrinkles of 36.0% after 4 weeks of treatment. However, the effectiveness of Formula III remained lower than that of the commercial clay mask. Conclusion: Ethanol extract of Hibiscus rosa-sinensis can be formulated as a stable and safe anti-aging clay mask. The 10% concentration formula exhibited the best effectiveness in improving skin aging parameters, although further formula optimization is still required to approach the effectiveness of commercial products.

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Journal Info

Abbrev

jps

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Description

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, ...