<![CDATA[Peperomia pellucida is a wild plant traditionally known to be rich in secondary bioactive compounds and has great potential as a natural antidiabetic agent. This study aimed to test the effect of Peperomia pellucida extract on blood glucose levels and leukocyte counts in male white rats (Rattus norvegicus). An experimental study using a Completely Randomized Design (CRD) consisted of 6 treatment groups with 4 replications over 28 days. Rats were conditioned to hyperglycemia using alloxan and then treated with distilled water (P0), 0.5% Na-CMC (P1), 5 mg glibenclamide (P2), and Peperomia pellucida extract at doses of 400 mg/kg BW (P3), 500 mg/kg BW (P4), and 600 mg/kg BW (P5). Data were analyzed using Welch's ANOVA followed by the Games-Howell post hoc test. The results showed that rats treated with Peperomia pellucida extract at all doses (400, 500, and 600 mg/kg BW) exhibited a significant reduction in blood glucose levels with similar effectiveness among doses (p < 0.05). In contrast, no significant differences in leukocyte count were observed among treatment groups (p > 0.05). It can be concluded that treatment with Peperomia pellucida extract at a dose of 400 mg/kg BW for 28 days exhibited antihyperglycemic activity without affecting leukocyte parameters during the treatment period.]]>
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