<![CDATA[ABSTRACT Therapeutic success in patients with type 2 diabetes mellitus is influenced by patient-related factors, including knowledge and medication adherence, which contribute to clinical outcomes. This study aimed to analyze knowledge and medication adherence as determinants of clinical outcomes in outpatients with type 2 diabetes mellitus. A cross-sectional study was conducted involving 189 respondents. Variables included patient characteristics, knowledge level (DKQ-24 instrument), medication adherence measured using the MMAS-8, and clinical outcomes. Data were analyzed using the Chi-square test with a significance level of 0.05. The results showed that most respondents were aged >60 years (50.3%), female (61.9%), had a senior high school education (39.2%), and were unemployed (67.7%). The majority had moderate knowledge (52.4%), low medication adherence (55.6%), and unsuccessful clinical outcomes (77.8%). The Chi-square test showed a significant association between knowledge and clinical outcomes (p = 0.000), as well as between medication adherence and clinical outcomes (p = 0.000). In conclusion, knowledge and medication adherence are significantly associated with clinical outcomes and act as important determinants of therapeutic success in patients with type 2 diabetes mellitus. Keywords: Clinical outcomes; knowledge; medication adherence; MMAS-8; type 2 diabetes mellitus]]>
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