<![CDATA[Growing demand for sustainable energy has accelerated development of lignocellulosic bioethanol as a viable substitute for fossil fuels. This review presents a comprehensive evaluation of lignocellulosic bioethanol production from diverse agricultural residues as sustainable alternatives to fossil fuels, with emphasis on integrating feedstock characteristics, pretreatment technologies, enzymatic hydrolysis, and fermentation strategies within a single framework. Feedstocks examined include rice, wheat, corn, sugarcane, oil palm, kenaf, cotton, sesame, ramie, and soybean residue. Various pretreatment approaches, including dilute acid and alkaline treatments, steam explosion, deep eutectic solvents (DES), ionic liquids, microwave-assisted processes (MAP), nanoparticle-assisted hydrolysis (NAH), γ-irradiation, and biological delignification, are reviewed together with enzymatic saccharification and advanced fermentation systems. Fermentation configurations include separate hydrolysis and fermentation (SHF), simultaneous saccharification and fermentation (SSF), simultaneous saccharification and co-fermentation (SSCF), fed-batch, repeated-batch, and consolidated bioprocessing (CBP) using conventional and engineered microorganisms such as Saccharomyces cerevisiae, Scheffersomyces stipitis, Kluyveromyces marxianus, Zymomonas mobilis, recombinant Escherichia coli, and Clostridium. Reported ethanol titers exceed 90 g/L with yields approaching 0.57 g/g substrate under optimized conditions. This review further highlights current challenges and future directions involving inhibitor tolerance, pentose–hexose co-utilization, high-solid loading optimization, and scalable bioreactor integration for industrial implementation.]]>
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