<![CDATA[Background: The periorbital area is highly sensitive to oxidative stress, which triggers premature skin aging. Dayak onion (Eleutherine bulbosa) contains secondary metabolites that are potential natural antioxidants for protecting the periorbital area.Objectives: This study aimed to formulate an anti-aging eye cream using the ethanol extract fraction of Dayak onion with the highest antioxidant activity.Methods: A laboratory-based experimental design was used to evaluate the antioxidant activity and formulate it into an eye cream. The study was conducted from August to November 2024. Phytochemical screening was performed on powdered samples, ethanol extracts, and water, ethyl acetate, and n-hexane fractions. GC-MS analysis was performed on the water, ethyl acetate, and n-hexane fractions of the samples. The physical quality of the eye cream was evaluated, including its organoleptic properties, homogeneity, emulsion type, pH value, viscosity, spreadability, and adhesiveness. Data analysis included IC50 calculation and One-Way ANOVA testing. Results: The samples contained flavonoids, alkaloids, tannins, and saponins. GC-MS analysis identified 9,12-octadecadienoic acid, 9-octadecenoic acid, and hexadecanoic acid, whereas coumarin was found in the water and ethyl acetate fractions. The ethyl acetate fraction exhibited the highest antioxidant activity, with an IC50 of 25,12 ± 5,14 ppm. The Dayak onion eye cream met the requirements for homogeneity, viscosity, and adhesion, but its spreadability and pH values exceeded the standards. The eye cream demonstrated strong antioxidant activity, with an IC50 of 99,43 ± 12,39 ppm.Conclusion: The anti-aging eye cream possesses strong antioxidant activity with an IC50 of 99,43 ± 12,39 ppm and fulfills the physical quality criteria for homogeneity, adhesiveness, and viscosity.]]>
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