This study aims to analyze the effect of Return on Assets (ROA), Earnings Per Share (EPS), and Debt to Equity Ratio (DER) on Stock Returns in pharmaceutical sub-sector manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2021–2024 period. This research employed a quantitative method with an associative approach. The results of the study indicate that: (1) Return on Assets (ROA) has no significant effect on Stock Returns, as evidenced by the t-value of -1.019, which is smaller than the t-table value of 2.03452; (2) Earnings Per Share (EPS) has no significant partial effect on Stock Returns, as indicated by the tvalue of 0.486, which is smaller than the ttable value of 2.03452; (3) Debt to Equity Ratio (DER) has no significant partial effect on Stock Returns, with a tvalue of -2.019, which is smaller than the ttable value of 2.03452; (4) ROA, EPS, and DER simultaneously have no significant effect on Stock Returns, as indicated by the Fvalue of 1.768, which is smaller than the Ftable value of 2.90; and (5) the variation in Stock Returns is explained by ROA, EPS, and DER by 14.2%, while the remaining 85.8% is influenced by other factors outside the research model that were not included in this analysis.
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