Mental disorders are often perceived as problems that do not directly cause death but havelong-term effects on physical health, leading to an individual's inability to self-care, the risk of suicide, and the riskof self-harm or harm to others. Mental disorders manifest as disturbances in thought, behavior, and feelings,characterized by a cluster of meaningful symptoms and behavioral changes that can cause suffering and impairan individual's ability to function socially and economically. To determine whether there is a correlationbetween family knowledge and motivation with medication adherence in patients with mental disorders at RSUD(Regional Public Hospital) Ajibarang. This study employed a quantitative method with a cross-sectionaldesign. The sampling technique used accidental sampling with a sample size of 53 respondents who met the inclusion and exclusion criteria. This study's results show a correlation between family knowledge andmedication adherence in patients with mental disorders, with a p-value of 0.000 (p0.05). There is also acorrelation between family motivation and medication adherence in patients with mental disorders, with a p-valueof 0.000 (p0.05). Conclusion: There is a correlation between family knowledge and motivation with medicationadherence in patients with mental disorders in the service area of RSUD Ajibarang.
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