This study aims to describe the effectiveness of the betel-chewing ethnoscience-based discovery learning model in improving students' critical thinking skills on acid-base material. The population of this study was eleventh-grade students of SMA Muhammadiyah 2 Bandar Lampung in the 2025/2026 academic year. The research sample was determined using the cluster random sampling technique, with Class XI B as the experimental class and Class XI C as the control class. The study employed a quasi-experimental method with a pretest-posttest control group design. The effectiveness of the model was analyzed using the two-mean difference test (t-test) and effect size test on students' critical thinking skills. The results showed that the average pretest score in the experimental class was 51 and in the control class was 38, while the average posttest score in the experimental class was 87 and in the control class was 62, with an average n-Gain of 0.74 in the experimental class (high category) and 0.38 in the control class (moderate category). The two-mean difference test showed a significance value of <0.001, indicating a significant difference between the two classes. The effect size test showed a result of 0.90 in the experimental class, indicating a large effect. Based on these results, it is concluded that the betel-chewing ethnoscience-based discovery learning model is effective in improving students' critical thinking skills on acid-base material
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